- 주제: Acoustic Wave Brain Stimulation in Stroke Therapy
- 일시 및 장소: 11월 29일 오전 10시30분, R715
- 연사: Ming-Yen Hsiao, M.D., Ph.D., CIPS, Associate Professor, National Taiwan University College of Medicine
- 내용: Focused ultrasound (FUS) has been applied in various therapeutic brain applications, including thermal ablation for treating essential tremor and blood-brain-barrier (BBB) opening for targeted drug delivery. We have developed focused shockwave (FSW) ultrasound-mediated BBB opening and a novel FSW-mediated blood-cerebrospinal fluid barrier (BCSFB) opening technique, both of which facilitate the delivery of drugs to the central nervous system (CNS) with demonstrated efficacy and safety in various disease models. Ultrasound-mediated neuromodulation, which involves the direct interaction with neurons, has also gained recognition for its potential in depth-penetrating, precise brain stimulation. This could offer target-specific neuromodulation for a range of CNS conditions. Another promising application is FUS-mediated glymphatic modulation, which may address pathologies linked to impaired glymphatic system function, such as stroke, traumatic brain injury, Alzheimer’s disease, and hydrocephalus. In our stroke animal model, we observed a rapid increase in cerebrospinal fluid (CSF) influx following FUS stimulation. After inducing a photothrombotic stroke, CSF influx significantly decreased. Remarkably, daily contralesional FUS treatments restored the impaired CSF influx. These results highlight the potential of ultrasound-based techniques in modulating CSF dynamics for stroke treatment. Acoustic wave brain stimulation presents a versatile approach in CNS disease management and neuroscience research. It offers improved tissue penetration and spatiotemporal resolution, enabling in vivo target-specific modulation of neural circuits, and holds promise for developing novel therapies for CNS diseases.
- 주관: 배수아 교수 연구실